Compromised antigen presentation ranks among the top mechanisms that render cancers non-immunogenic (non-responsive to immune ...

This is the result of an elegant evolutionary process that equipped T cells with a sophisticated surveillance system: the human leukocyte antigen (HLA) presentation pathway. When the proteasome breaks ...

to recognize their antigens, which are often in the form of peptides bound to major histocompatibility complex molecules (MHC), also called HLA (human leukocyte antigens) in humans. Desire to identify ...

"We needed to make a new type of cell, because we were trying to target specific antigens called peptide-HLA (human leukocyte antigen ... Jacqueline Douglass, Emily Han-Chung Hsiue, Stephanie ...

These cells could be efficiently expanded in vitro and used to stimulate T cells of any patient of a given human leukocyte antigen (HLA) type. These workers demonstrated potent induction and ...

human leukocyte antigen; MM, multiple myeloma; MRD, minimal residual disease; NSCLC, non–small cell lung cancer; Ph–, Philadelphia chromosome negative; R/R, refractory or relapsed. The aim of our work ...

The etiology of TRALI remains incompletely understood; antibodies directed against a human leukocyte antigen (HLA) or another neutrophil antigen are thought to cause the disease 2. These ...

The also had the highest overall non-human leukocyte antigen genetic risk score. Perspective from Christopher J. Sayed, MD Researchers reported a shared genetic susceptibility of psoriasis and ...