Although the definitions are arbitrary, from a clinical viewpoint, insulin replacement consists of prandial (bolus) insulin, basal insulin, and a correction-dose insulin supplement. 6 Prandial ...

We propose that pharmacological agents targeting hypothalamic glucose-sensing pathways may represent novel therapeutic strategies for enhancing early phase insulin secretion in type 2 diabetes.

Conclusions: This study demonstrated that nateglinide improves mealtime and mean glycemic control in a dose-dependent manner by restoring early insulin secretion phase. Nateglinide was well ...

The resultant A-chain was purified using a Reversed-phase high-performance liquid ... leading to compensatory insulin secretion, plasma hyperinsulinaemia and thus insulin resistance as shown ...

in response to glucose—a process that is aptly called glucose-stimulated insulin secretion (GSIS). DA negatively regulates GSIS, leading to transient changes in the body's levels of insulins.

However, in people with overweight or obesity, an excessive inflammatory response during the cephalic phase can impair this insulin secretion. “This study highlights the complexity of our ...

The major driver of insulin secretion is glucose, produced when carbohydrates are broken down. However, the effect that the other main classes of macronutrients – proteins and fats – have on ...