This cell cluster may look jumbled, but it is well organized. Called a glomerulus, it’s a cluster of cells from a kidney; it filters and processes blood to maintain proper levels of water, salt, and ...

In summary, this study highlights the importance of recognizing high blood pressure as not just a heart risk, but also a ...

The disease is marked by the buildup of C3 protein in the kidney glomeruli as a result of overactivation of the alternative complement pathway, triggering inflammation and kidney damage.

Iptacopan is the only oral inhibitor of the alternative complement pathway to selectively target the underlying cause of the C3G, a disease that causes inflammation and damage to the kidney glomeruli, ...

According to the National Kidney Foundation, glomerular diseases damage the glomeruli—the tiny filters in the kidneys—and impair kidney function. Focal Segmental Glomerulosclerosis (FSGS ...

Podocytes are specialized cells of the renal corpuscles (glomeruli) that play a crucial role in the filtering function of the ...

The US Food and Drug Administration (FDA) has approved iptacopan (Fabhalta) as the first treatment to reduce proteinuria in adults with complement 3 glomerulopathy (C3G). This rare kidney ...

People with chronic kidney disease, for example, may have high levels. If the glomerulus — the part of the kidney that filters waste — is damaged or otherwise not working efficiently ...

“These changes show that high blood pressure alone, even without diabetes, can begin to harm the kidneys,” said lead ...

Kidney disease usually cannot be cured ... One complication is high blood pressure, which further damages glomeruli. Some patients may benefit from limiting protein in their diet to reduce ...

A research team has investigated structural changes in kidneys of patients with hypertension and type 2 diabetes. The results show that high blood pressure can lead to abnormalities in the podocytes, ...