With over 15 years of experience in kinase drug discovery, DiscoverX offers the largest collection of nearly 500 biochemical and cell-based kinase assays. KINOMEscan® technology, our novel kinase ...

Learn about our Editorial Policies. Gerard Drewes and his colleagues at Cellzome, a German biotech company, created nonspecifically binding compounds called “kinobeads” to screen kinase inhibitor drug ...

Kinases are crucial for cellular signaling, and their dysregulation is tied to many diseases. Kinase selectivity profiling is essential in drug discovery. SignalChem Biotech, part of Sino Biological, ...

Kinomic profiling is achieved using the PamStation®12 Platform ... will be loaded per well of the PamChip along with standard kinase buffer (Supplied by PamGene), 100 μM ATP, and FITC-labeled ...

Using the approach, the authors were able to profile clinically-relevant kinase inhibitors against 178 different kinases, of which 115 targets are available for profiling at Reaction Biology.

The approval of two kinase-targeting drugs ... developed in collaboration with Millipore (Upstate) for profiling and high-throughput screening of serine/threonine kinases and tyrosine kinases.

An emphasis of the core is to develop personalized medicine approaches through evaluation of kinomic profiles in tumor specimens coupled with ex vivo profiling of small molecule inhibitors (kinase ...