Operationally, mutated proteins that induce the development of the leukemic phenotype (oncogenes ... pathways in the same leukemic cell. Tyrosine kinases are important elements of signal ...
What regulates protein kinase activity during cell division? Interestingly, protein kinases phosphorylate each other as well as act on common targets. Aa Aa Aa The cell cycle allows faithful ...
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Among the p53 target genes are WAF1, an inhibitor of cyclin-dependent protein kinases (CDKs ... In the RB pathway, stress signals such as oncogenes induce INK4A, the other product of the CDKN2A ...
An additional notion that emerges from these studies is that myeloid leukemia is a polygenic disease that requires the cooperation between different oncogenes for disease development (a concept ...