The team is optimizing the cancer genome analysis system to integrate it into CRC diagnosis and tailor treatments based on ...

Researchers used mutational analysis to identify gene mutations that may drive carcinogenesis in colorectal tumors with high ...

KRAS G12C inhibitors mark a breakthrough in oncology, but resistance is driving the need for smarter preclinical models and ...

In a recent study, precancerous pancreatic lesions and some pancreatic ductal adenocarcinoma (PDAC) tumors harboring KRAS mutations had higher-than-normal expression of the FGFR2 protein ...

Colorectal cancer (CRC), a type of cancer that affects the large intestine and rectum, is one of the leading causes of cancer ...

Researchers at City of Hope®, one of the largest and most advanced cancer research and treatment organizations in the U.S. with its National Medical Center named top 5 in the nation for cancer by U.S.

"While the KRAS mutation has suggested a strong therapeutic ... "Transcription-replication conflicts are more prevalent in cancer cells than normal cells," Dr. Raoof said. "Therapies that ...

Johns Hopkins Medicine scientists say they have found a pattern of so-called epigenetic "marks" in a transition state between ...

City of Hope researchers demonstrate proof of concept for a novel targeted therapy for pancreatic cancer, exploiting transcription-replication conflicts to combat treatment resistance.

Moreover, a step-wise colorectal carcinogenesis model has been proposed wherein normal epithelial ... acquire genetic mutations. Mutations in APC, TP53, KRAS, and PIK3CA genes have been frequently ...

“Epigenetic changes have long been a focus of research seeking to explain how cells transition from normal to cancer,” says Andrew ... which are caused by a mutation in a gene called KRAS, even though ...

"While the KRAS mutation has suggested a strong therapeutic ... "Transcription-replication conflicts are more prevalent in cancer cells than normal cells," Dr. Raoof said. "Therapies that ...