Some gamers with particularly large hands may still experience discomfort ... The journey to find the ideal gaming mouse for big hands may be daunting, but it's worth the effort.

Wireless mice have become so inexpensive and reliable that, for most people, they’re a better option than a cheap wired mouse ... and it’s too large for those with small hands.

The GlassOuse is a bluetooth mouse that's worn like glasses. Based on your head movements, it moves the cursor onscreen. You bite on a blue extension to click, and it can go a week without charging.

The G203 is still on the smaller side and not the best mouse for big hands. However, its hump slopes high enough to feel secure in most palms. A standard layout includes two left-side buttons.