Both variants bind to the leptin receptor but trigger marginal ... Details on protein structure modeling, activity, binding, internalization, and competition studies are provided in the ...

Although previous research has shown that the hormone leptin acts directly on hunger neurons through leptin receptors to promote the development ... development may exert lasting effects on the ...

The study showed that a molecule that targets a specific group of neurons with both GLP-1 receptors and leptin receptors produced more weight loss in mice than molecules mimicking either hormone ...

Although previous research has shown that the hormone leptin acts directly on hunger neurons through leptin receptors to promote ... exert lasting effects on the structure and function of circuits ...

Leptin effects are through the leptin receptor which is part of the cytokine receptor family. Mutations in the genes that code for leptin or for the receptor can cause morbid obesity early in life ...

Leptin inhibits ghrelin in two ways; it reduces ghrelin secretion by gastric cells and suppresses ghrelin receptors' expression in the NPY system, therefore preventing the stimulation of feeding ...

Panel A shows the weight curve for the patient, as compared with normal percentiles for boys of his age, before and after the start of treatment with metreleptin. Panel B is a photograph of the ...

"We now think that people with naturally high levels of leptin receptors may not gain weight as rapidly over time as people who have low levels of leptin receptors," said Dr. Unger. "It could ...

Although previous research has shown that the hormone leptin acts directly on hunger neurons through leptin receptors to promote ... exert lasting effects on the structure and function of circuits ...