mTOR is theoretically well placed to sense and signal nutrient and energy levels within the same neural circuits on which leptin acts to regulate energy balance. 57, 58 Two mTOR complexes exist ...

Given that hypothalamic insulin and leptin signaling pathways overlap 2, we investigated the physiological role of ROCK1 in hypothalamic control of food intake and body weight, with particular ...

Key molecules along the leptin signaling pathway have been elucidated in studies involving patients with rare monogenetic causes of obesity (e.g., mutations in the genes encoding leptin ...

In "Leptin Receptor Neurons in the dorsomedial hypothalamus require distinct neuronal subsets for thermogenesis and weight loss," researchers laid out the pathways, chemicals, neurons and brain ...

Leptin is a hormone with a range of functions ... suggesting the molecule can enter the brain and plausibly affect appetite signaling. When GIP activity in the brain was blocked in obese animal ...