A multi-institutional team developed a chimeric antigen receptor (CAR) T cell-based strategy for specifically targeting AML cells in patients who relapsed following other treatments. The team ...

These engineered cells were resistant to fratricide and displayed potent antitumor activity both in culture and in a xenograft mouse model of T cell acute lymphoblastic leukemia (T-ALL). CAR T ...

Using human T cells and leukemia cells in specialized mouse models, researchers developed the novel ALA-CART cells which showed promising results in fighting acute lymphocytic leukemias that were ...

CAR T cells have been highly successful in individuals with B cell leukemia/lymphoma and multiple myeloma (MM ... as well as ...

For example, chimeric antigen receptor (CAR) T–cell immunotherapy causes an initial response in 90% of B-cell acute ...