Mechanical forces along a polymer backbone can be used ... the fact that the mechanical advantage of the lever-arm effect outweighs the advantage obtained by increasing the intrinsic reactivity ...

Figure 1: Detection of the lever-arm swing and Brownian search-and-catch by a single myosin-V dimer. Figure 3: Detection of 20 nm and −20 nm lever-arm swings. To estimate the probability of a ...