Ligand-gated ion channels are ion channels that are opened or closed (gated) by ligands, generally small molecules such as the second messenger cAMP and neurotransmitters. Ligand-gated ion ...

An innovative use of HSV-1 vectors lays the foundation for a novel genetic screen for modulators of ligand-gated ion channels. Ion channels regulate important physiological responses in excitable ...

Ligand-gated ion channels (LGICs) represent an important class of drug targets that play a critical role in the function of the central nervous system. Compounds acting on ligand-gated channels ...

Cite this: Targeting Ligand-gated Ion Channels in Neurology and Psychiatry: Is Pharmacological Promiscuity an Obstacle or an Opportunity? - Medscape - Mar 02, 2010.

such as a change in membrane potential (voltage-gated ion channels) or the binding of a neurotransmitter (ligand-gated ion channels). The voltage-gated ion channels allow permeation of only one ...

The process of expressing a wide variety of voltage-gated and ligand-gated ion channels enables nociceptors to transduce receptor potential into single action potentials or multiple action potentials.

The PatchXpress® 7000A patch clamp system is an automated electrophysiology workstation that allows users to increase throughput of research quality recordings and to measure ion channel activity from ...

Marc then left academia to start a new career in ion channel drug discovery, beginning at Exelixis in the Bay Area before moving to the UK in 2005 to work at Xention on voltage- and ligand-gated ion ...

Cite this: Targeting Ligand-gated Ion Channels in Neurology and Psychiatry: Is Pharmacological Promiscuity an Obstacle or an Opportunity? - Medscape - Mar 02, 2010.