Just as life pulsates in big vibrant cities, it also prospers in crowded environments inside cells. The interior of cells is densely packed with biomolecules like proteins and nucleic acids. How is ...

Researchers at the Francis Crick Institute have shown that the 'pacemaker' controlling yeast cell division lies inside the nucleus rather than outside it, as previously thought. Having the pacemaker ...

The authors set out to answer a simple question. Do all chromosomes have the same chance of being mis-segregated during cell division? To address this, Klaasen and colleagues turned to several types ...

An international team of scientists has unveiled the most comprehensive model yet that explains how cells control the flow of materials in and out of their nuclei—solving one of biology's oldest ...

The nucleus is guarded by a highly secure door, the so-called nuclear pore, that controls the transport of substances from the cytoplasm to the cell nucleus and back. A research group has now shown ...

Around one million individuals worldwide become infected with HIV, the virus that causes AIDS, each year. To replicate and spread the infection, the virus must smuggle its genetic material into the ...

Rush hour never ceases at the nucleus’ border. Gene products begin their lives in the nucleus as strands of mRNA that ship out into the cytoplasm, where they serve as templates for protein synthesis.

In order for HIV to replicate, the viral genome must enter into the cell nucleus and integrate into the host cell chromosome. Previous work suggests that the entry proceeds through nuclear pore ...