[40] Patients may be at higher risk of developing fractures and this may be related to the dose or the duration of use of PPIs. If long-term PPI therapy is to be used, monitoring of bone density ...

However, to use ... term treatment. In most cases, they are well-tolerated. Still, they have a risk of mild to serious side effects, especially if they are taken over a long period. All PPIs ...

Higher risk in patients who receive high-dose (multiply daily doses) and long-term PPI therapy (1 year or longer). Use the lowest dose of Protonix and for the shortest duration of PPI therapy ...

[6] Acid-related disorders frequently require long-term medical therapy and patients ... suggest that concomitant use of clopidogrel and a PPI reduces the antiplatelet effects of clopidogrel.

Higher risk in patients who receive high-dose (multiply daily doses) and long-term PPI therapy (1 year or longer). Use the lowest dose of Protonix and for the shortest duration of PPI therapy ...

Temple raised the question of running a large, long-term trial, similar to the National ... Ideally, said Temple, aspirin plus a proton-pump inhibitor (PPI) would be included too.