30 The nephron comprises a set of anatomically and molecularly distinct segments, arranged in a series, each contributing to net sodium ion reabsorption (Figure 3). Loop diuretics primarily ...

Future Cardiol. 2012;8(5):707-728. These data come from reports of ototoxicity of 6.4% with furosemide compared with 1 and <1% for bumetanide and torsemide, respectively. [38] Acute kidney failure ...

This review focuses on thiazides, the diuretics most often indicated for long-term therapy for hypertension; loop diuretics and ... hypertrophy of distal nephron segments. 29–31 Tolerance ...

Both thiazides and loop diuretics cause the body to lose potassium ... channels to principle cells in the collecting duct of the nephron but drugs such as spironolactone block aldosterone ...

Strategies to combat diuretic resistance include sequential nephron blockade with combination loop and thiazide or thiazide-like diuretics. In addition, favorable outcomes have been demonstrated ...