TGN sorting of lysosomal membrane proteins. The studies on LIMP2 and βGC underline the central role of LMPs in lysosome biogenesis and lysosome functioning, ...

Because the STING protein has multiple functional regions spanning the cell membrane, the researchers did additional experiments to determine which region might be responsible for lysosome generation.

Lysosomes are membrane-bound organelles in cells that act as recycling centers—breaking down ... The autophagy protein ATG-9 regulates lysosome function and integrity, Journal of Cell Biology ...

In VSP35 knockouts, transmembrane proteins were depleted where they belong—at the membrane—yet enriched in lysosomes, suggesting membrane protein recycling had become backed up. On the other hand, ...

The final step of the membrane repair operation occurs when phosphatidylserine activates a protein called ATG2, which acts like a bridge transporting other lipids to the lysosome to seal any remaining ...

CHICAGO (CBS) -- Lysosomes – membrane-bound structures within each cell of humans and all animals – are sometimes known as the cells' "garbage disposals" or "cellular janitors." The structures ...

Li's lab studies the lysosome, and in particular, the composition of lysosome membrane proteins. The lysosome has the ability to regulate its own membrane protein by triggering the degradation of ...

Li's lab studies the lysosome, and in particular, the composition of lysosome membrane proteins. The lysosome has the ability to regulate its own membrane protein by triggering the degradation of ...

Proteins are conventionally trafficked and secreted ... The KFERQ-like motifs of monomeric PARK7 selectively bind to HSPA8 chaperones and are recruited to the lysosomal membrane, ...