"Part of the problem has been an inability to measure calcium inside the lysosome," said Matthew Zajac, Ph.D., the first author of the paper. "Because it's a highly acidic compartment, it's been ...

The maturation of early endosomes into lysosomes is marked by a progressive decrease in interior (luminal) pH, which is crucial for the activation of resident enzymes that degrade exogenous ...

De Duve named these new organelles "lysosomes" to reflect their lytic nature. That same year, Alex Novikoff from the University of Vermont visited de Duve´s laboratory. An experienced ...