The vesicle then ferries the cargo to a membrane-bound organelle within the cell called a lysosome that is filled with digestive enzymes. Researchers suspected that microglia could also break down ...

The STING protein, known for helping cells fight viral infections by generating inflammation, also appears to function as a ...

Microglia are a type of small macrophage-like glial cell in the central nervous system. Microglia can engage in phagocytosis, and are involved in immune responses within, as well as the ...

A new way to deliver disease-fighting proteins throughout the brain may improve the treatment of Alzheimer's disease and other neurological disorders, according to scientists. By engineering human ...

For one, microglia hovering around plaques—the type that express the most TREM2—reportedly become desensitized to stimulation ...

A new way to deliver disease-fighting proteins throughout the brain may improve the treatment of Alzheimer's disease and ...

Lysosomes are membrane-bound organelles in cells that act as recycling centers—breaking down waste materials, damaged ...

Evidence suggests that in Parkinson’s disease, a breakdown in lysosomal function allows lipids to build up within cells. Variants of the GBA1 gene, the strongest genetic risk factor for sporadic PD, ...

Gedam, M., Comerota, M.M., Propson, N.E., Chen, T., Jin, F., Wang, M.C., and Zheng, H. Complement C3aR depletion reverses HIF-1α-induced metabolic impairment and ...