Figure 1: Phylogenetic correlation among kinases in Cryptococcus neoformans ... osmolarity glycerol response (HOG) MAPK, and the pheromone-responsive MAPK pathways were clustered together based ...

Many of these pathways belong to what is now termed ‘the mitogen-activated protein kinase (MAPK) superfamily.' These pathways have been linked to the growth factor-mediated regulation of diverse ...

Many cancers harbor pro-proliferative mutations of the mitogen-activated protein kinase (MAPK) pathway. In BRAF-driven melanoma cells treated with BRAF inhibitors, subpopulations of cells escape ...

Conversely, studies using mice with disruption of the genes that encode the p38 kinases have demonstrated enhanced transforming potential of fibroblasts, indicating a potential role of the p38 MAPK ...

The MAPK pathway is a "signaling hub" for cells important to the usual development of the head and neck region, and activating key pathway constituents, like the genes MAPK1 and HRAS, is known to ...

Patients can still talk to their clinicians about enrolling in a sub-study of the FIRELIGHT-1 trial, analyzing tovorafenib plus pimasertib in progressive or refractory solid tumors with MAPK pathway ...

MAPK-pathway upregulation is the main event in the development and progression of human cancer, including melanoma and recent studies have shown that MALAT1 has a significant impact on the ...

The team demonstrated that tumor cells make new fat through the KRAS-MAPK pathway. "KRAS is the master regulator of pancreatic cancer, and new medicines are now in clinical trials to bring down ...

These pathways, mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K)–AKT, lead to maturation of heart cells, allowing them to adapt functionally to their postnatal role.

Mitogen-activated protein kinase (MAPK) and Wnt signaling pathways are critical for melanocyte development and melanogenesis and could be novel therapeutic targets for modulating melanin synthesis.