Early clinical results of this approach targeting the Mitogen-activated protein kinases (MAPK) pathway are promising. In our Season 2 of the Pivot podcast — spanning from April through June ...

The team demonstrated that tumor cells make new fat through the KRAS-MAPK pathway. "KRAS is the master regulator of pancreatic cancer, and new medicines are now in clinical trials to bring down ...

The degree of complexity and crossover within MAPK signaling, and also shifts in pathways such as nuclear factor κB signaling, could also explain the modest effect of p38 inhibitors. The p38α ...