These observations suggest a complex regulation relationship between ... regulates the expression of MLH1 protein and the MLH1-PMS2 heterodimer (MutLα) positively regulates the processing of ...

The MLH1 protein works with another protein called PMS2 to form a complex, which essentially directs the activities of other proteins that repair DNA errors. Yes, genetic testing is available to ...

Germ-line mutations in the mismatch-repair genes MLH1, MSH2, MSH6, and PMS2 lead to the development ... would be similar to that of the more complex strategy of genotyping for microsatellite ...

At the time of initial (pretreatment) diagnosis, immunohistochemical analysis was performed to detect the expression of MLH1, MSH2, MSH6, and PMS2 (in 12,185 specimens) or MSH6 and PMS2 only (in ...

Once colon cancer is identified, European and American guidelines recommend considering an extended colorectal surgery for patients of Lynch syndrome carrying the 'path_MLH1' and 'path_MSH2' gene ...