Methotrexate (MTX) has been used for rheumatoid arthritis (RA) treatment since 1980. It is the most common effective disease-modifying antirheumatic drug (DMARD) for RA, and is considered to be ...

Previous use of DMARDs, including methotrexate, was permitted ... effect on B lymphocytes may have a role in the mechanism of action of T-614”. Elevated plasma alanine transferase levels ...