GM-CSF also has profound effects on the functional activities of various circulating leukocytes. It is produced by a variety of cell types including T cells, macrophages, endothelial cells and ...

As these tight junctions deteriorated, more blood proteins and T cells infiltrated the CSF. As mice aged, macrophages in the choroid plexus secreted more cathepsin S, breaking down the blood-CSF ...

An alternative strategy is to target cells in the glioma microenvironment, such as tumor-associated macrophages and microglia (TAMs). Macrophages depend on colony stimulating factor-1 (CSF-1 ...

Depleting perivascular macrophages weakens CSF flow and protein clearance. The cells die off with age and are altered in Alzheimer’s brain. Stimulating macrophages restores flow, suggesting these ...

Macrophages differentiate into foam cells during the formation and progression ... such as macrophage colony-stimulating factor (M-CSF), which induce the differentiation of more monocytes into ...

Macrophage cells responsible for the development of adaptive immune responses were isolated from their blood. The authors then studied the effect that G-CSF exerts on these cells. As a result ...

Repurposing existing therapies may help slow muscle weakness in patients with Duchenne muscular dystrophy, a new study ...

The basal capacity of isolated neutrophils to phagocytose opsonized fluorescent microspheres was evaluated as previously described for macrophages ... GM-CSF, using TF1 cells as previously ...

Microglia, the resident immune cells in the brain ... using specific colony-stimulating factors (CSFs): granulocyte-macrophage CSF (GM-CSF) induced a pro-inflammatory "M1-like" phenotype, while ...

Recent advances in cancer research have underscored the critical role of myeloid cells in shaping tumor microenvironments ...

CSF-1 stimulates resident macrophages in skeletal muscles to proliferate ... Researchers continue to refine gene therapy and cell therapy approaches for DMD, which have so far shown limited ...