Background Current treatments with tyrosine kinase inhibitors and immune checkpoint inhibitors have limited efficacy for ...

Macrophages and other immune cells are the natural frontline immune warriors of our body, defending the body against invading ...

One of the key findings from this research is that when macrophage identify antibodies on the surface of a cancer cell, they don't immediately begin phagocytosis. Instead, they first rearrange the ...

They also observed an elevated oxygen consumption rate, suggesting that phagocytosis of bacteria fuels the mitochondrial respiratory chain. To trace the fate of phagocytosed bacteria, Garaude and his ...

The study found that M-CSF-induced macrophages (M-CSF MΦ) from typically developed individuals were more efficient at phagocytosis—engulfing and clearing synaptosomes—compared to GM-CSF ...

Macrophages are innate immune cells involved in the detection, phagocytosis and destruction of bacteria and other harmful organisms, including cancer cells. However, cancer cells can evade clearance ...

This enables macrophage-mediated phagocytosis of CLDN18.2+/CD47+ tumor cells, thereby enhancing the antitumor activity of immune cells. On the other hand, AK132 also induces potent tumor cell ...

The presented data show that PHST001, through potent CD24 binding, promotes macrophage-induced phagocytosis in a number of cancer cells and significantly shrinks tumors in vivo. In addition ...

When CD47 on tumor cells bind with SIRPα on macrophages, the macrophages suppress phagocytosis. 2 Astellas' R&D strategy: Astellas has established a Focus Area Approach for its research and ...

YF550-C1, an E3 ligase inhibitor of CBL-B, to demonstrate T cell and NK cell activation and anti-tumor activities in syngeneic and PDX tumor model. This is an ASCO Meeting Abstract from the 2024 ASCO ...