Macrophages serve as the Swiss army knives of the innate immune system, switching between phenotypes to perform different functions in response to the surrounding environment. One of their key ...

activating nearby antigen presenting cells (APCs), notably dendritic cells (DCs), and repolarizing tumor-associated macrophages (TAMs) toward an M1 phenotype. In addition to direct phagocytosis of ...

Macrophage metabolism is crucial in this polarization because the shift from oxidative phosphorylation to glycolysis powers the inflammatory M1 phenotype during sepsis. This metabolic shift ...

our aim is to actually keep them in the tissue and change their phenotype from being immune suppressive to immune stimulatory.” Bregenholt hopes that with this approach Macrophage, and its lead ...