Using zebrafish to understand the molecular identity of nephron progenitors and the pathways that regulate them may lead to therapeutic ways to activate, or artificially engineer, the mammalian ...

Reference: Bugacov H, Der B, Briantseva BM, et al. Dose-dependent responses to canonical Wnt transcriptional complexes in the regulation of mammalian nephron progenitors. Development.

Without functioning Neph1 and Nephron, kidneys do not filter properly, leading to neuropathy. Alterations within nephrons also have been linked to hypertension. The mammalian-kidney versions and ...

In development of the mammalian kidney ... in embryonic mice. "Nephron progenitor cells cease to exist by the time humans are born," said Helena Bugacov, who is a first author on both studies ...

How and why is an SGLT2 inhibitor protective of the kidneys? The working units of the kidney are individual nephrons; each nephron is formed by a glomerulus, which filters fluid from the blood ...