[19] This may be the other mechanism of action of Silymarin in the treatment of melasma. Silymarin inhibited l-DOPA oxidation activity of tyrosinase, the rate-limiting melanogenic enzyme ...

"For melasma, retinol can be used as a stand-alone topical and is also commonly prescribed as a combination cream," says Dr.

For those expecting mamas or mamas who just gave birth, we’re sure one pesky skin problem you never considered before was melasma ... You apply this cream both day and night.