Microglial Activation: Understanding Neuroinflammation's Origins from thescientistllc on Vimeo. Microglia are the brain's resident immune cells, transitioning from resting to activation upon sensing ...

Study supported by the Michael J. Fox Foundation through a grant awarded to ZyVersa and leading inflammasome experts at ...

Interestingly, this process seemed to operate independently of NFAT5, suggesting multiple activation pathways are involved in the microglial response to hyperosmotic stress. Additionally ...

Could iMG be engineered to respond to specific pathologies in other diseases in which microglial activation is known to play a part? The scientists used breast cancer brain metastasis and multiple ...

Researchers have developed engineered human microglia that detect disease-related brain changes and release therapeutic ...

Specifically, the toll-like receptor 4 appears to be a site at which drugs of abuse activate microglia. Toll-like receptor 4 activation consequently produces an innate immune response in the brain ...

In PNS nerve injury or neurodegeneration, activation of PNS microglia may clear damaged tissues and promote neural regeneration. Besides, during viral infections, they may shield neurons from ...

The research demonstrates that IC 100 blocks microglial inflammasome activation and reduces neurotoxic alpha-synuclein accumulation—both key contributors to PD progression. “These are the ...

The blood-brain barrier border protects the brain by regulating the flow of molecules, peptides, and cells, but it also keeps out many therapeutics. Now, researchers have harnessed the power of a ...