The authors investigated the epigenetic mechanisms regulating the differentiation of circulating monocytes that infiltrate the CNS and adopt microglia-like characteristics. The work is useful to the ...

Trained immunity is reshaping our understanding of host defense by demonstrating that innate immune cells once thought to lack memory can be reprogrammed to mount heightened responses to subsequent ...

The coronavirus disease 2019 (COVID-19) pandemic underscored the need for the development of tools that can visualize immune system activity in the context of viral inflammation. Although [18F]FDG PET ...

(A) Volcano plot of DEGs in monocytes/macrophages between NC and CRC samples in the GSE164552 dataset. (B) Venn diagrams of common DEGs up- or down-regulated across the six scRNA-seq datasets (NC vs.

Selectively inactivating a molecular switch that turns on the gene Nr4a1 in monocytes but not macrophages leads to the loss of patrolling monocytes, which play an important role in suppressing lung ...

Combining a serum-free medium with a xeno-free serum replacement creates a reliable system for generating functional dendritic cells and macrophages. Myeloid cells such as dendritic cells and ...

A recent study posted to the bioRxiv* preprint server reported that helminth exposure enhances viral clearance and survival of mice challenged with severe acute respiratory syndrome coronavirus 2 ...

Steatotic liver disease (SLD), mainly encompassing metabolic dysfunction-associated steatotic liver disease (MASLD), alcohol-related liver disease (ALD), and metabolic dysfunction and ALD (MetALD), ...