“DNA damage in cells induces the expression of inflammatory ... of DNA lesions and coordinated by either ataxia-telangiectasia mutated (ATM) or IRAK1 kinases.” “This discovery could have ...

More information: Xing Kang et al, Extrachromosomal DNA replication and maintenance couple with DNA damage pathway in tumors, Cell (2025). DOI: 10.1016/j.cell.2025.04.012 Provided by Chinese ...

Each time a cell divides and DNA is replicated ... Environmental factors can influence how these mutated genes manifest. Damage to the structure of DNA can occur in various ways.

A unique feature of HR is that it repairs the damage to the DNA in a highly accurate way. In eukaryotic cells (those with a ...

New research from the Kind Group sheds light on how cells repair damaged DNA. For the first time, the team has mapped the activity of repair proteins in individual human cells. The study demonstrates ...

While lower levels of hydrogen peroxide produced by DAAO at the mitochondrial membrane did not damage DNA or pause the cell cycle, higher concentrations reduced cells’ viability. The researchers ...

Further investigation showed that papillomavirus colonization of the skin helps maintain skin health after UV damage. Papillomavirus-specific T cells prevent the growth of UV-mutated cells ...

Moreover, the team discovered that ecDNA replication triggers the ataxia telangiectasia mutated (ATM)-mediated DNA damage response (DDR) pathway. In ecDNA+ cells, there was an increase in both ...

DNA repair mechanisms ... the missing function. “Human cells love redundancy,” says Corn. Only when the backup is also switched off do they lose the ability to repair the genetic material. Sooner or ...