NNRTIs bind to a hydrophobic pocket near the catalytic site of HIV-1 RT and inactivate enzymatic activity. NNRTI-resistance mutations & their mechanism of drug resistance The most prevalent NNRTI ...

BEEHIVE follows individuals enrolled in eight cohorts across Europe and Uganda to understand better the molecular basis of HIV strains and which mutations in HIV's genetic sequence are associated ...

and confirms the need to clarify the fate of escape mutations in order to determine their future relevance to vaccine design. These findings also suggest that the role of CTLs in shaping HIV ...

Resistant individuals had in their cells two copies of a mutation that disrupted the entryway through which HIV viruses entered white blood cells. People who inherited just one copy of the change ...

A compound that blocks the CCR-5 protein might prevent HIV infection as if a person had naturally inherited the mutation. This discovery has not yet translated into new treatments. A dozen ...