The vast majority of persons infected with Mycobacterium tuberculosis remain asymptomatic for life; at least 90% of infected adults never become ill. What is the basis for resistance to tuberculosis?

The tuberculous granuloma has long been considered a key ... in the sole context of innate immunity and, rather than being mycobacterium-restricting structures, early granulomas actually expand ...

One of the host's first moves against the mycobacterium is the formation of a granuloma, an aggregate of cells, which consists of macrophages and other defensive immune cells. Although granulomas ...

This creates “caves” that trap Mycobacterium tuberculosis, known as granulomas. “[Granulomas] change over time, but they’re independent. So the environment that the bacteria are in in one granuloma ...

Despite this, it was not recognised as a cause of human disease until 1951 when it was isolated in the lesions of swimmers in a swimming pool in Sweden - thus the term ‘swimming pool granuloma’ was ...

Mice infected with the bacteria that cause tuberculosis (TB) fared better when treated with an experimental compound that modulates immune responses than untreated mice did, according to a study led ...

It has been uncertain how Mycobacterium tuberculosis deflects ... as they engaged in distinctive immunological phenomena like granuloma formation and alveolitis. These data implicate LDHA as ...