achieving consistent results and even uncovering a novel allosteric regulation mechanism in human β-cardiac myosin, a protein crucial to heart function. The development of the PATHpre model ...

Back in the 1980s, when Fowler started working with red blood cells, it wasn’t clear whether they even contained myosin. She suspected they might, because the protein appeared to play a role in giving ...

Specifically, troponin (the smaller protein) shifts the position ... Spudich, J. A. The myosin swinging cross-bridge model. Nature Reviews Molecular Cell Biology 2, 387–392 (2001) doi:10.1038 ...

In addition to assessing mutations in myosin proteins that lead to disease, we also work to understand physiologic heart muscle growth and loss using mouse and python as model organisms as ... are ...

The model suggests that changes in the volume ... volume changes altered the distribution of myosin, a key protein in cell contraction, and weakened tension. In mature crypts, myosin remained ...

In 2007, Kohsaka and colleagues developed a novel model of myositis that involved injecting B6 mice with fragments of recombinant skeletal C-protein, a myosin-binding protein that regulates the ...

The movement of cells in the human body – known as cell migration – is crucial for immune cells. These cells must move quickly and flexibly in different environments in order to fulfil their role as ...