achieving consistent results and even uncovering a novel allosteric regulation mechanism in human β-cardiac myosin, a protein ...

Specifically, troponin (the smaller protein) shifts the position ... Spudich, J. A. The myosin swinging cross-bridge model. Nature Reviews Molecular Cell Biology 2, 387–392 (2001) doi:10.1038 ...

In addition to assessing mutations in myosin proteins that lead to disease, we also work to understand physiologic heart muscle growth and loss using mouse and python as model organisms as ... are ...

Myosin II plays the most important role in cellular force generation. Myosin II molecules self-assemble into filaments with different structures depending on myosin II isoforms and other conditions ...