It is known that the gene product of NF1, neurofibromin, functions as a regulator of a protein called RAS. RAS is a key component of the RAS/MAPK cell signaling pathway that controls cell growth and ...

Tumor necrosis factor α-induced protein 3-interacting protein 1 ... only affects CCNG1 levels but also activates the NF-κB signaling pathway, leading to increased apoptosis in MCF-7 cells.

The authors discuss several major pathways involved in breast cancer, including PI3K/Akt/mTOR, RAS/RAF/MEK/ERK, HER2, Wnt/β-catenin, Notch, NF-κB ... tumor-suppressing protein called PTEN.

Protein Pathways is now employing in tandem two approaches—phylogenetic profiling and Rosetta stone analysis—that could take the identification of protein function to a new level. (Click here ...