Figure 1: Summary of applied TAD chemistry for click and transclick reactions. An overview of the possibilities and key aspects of TAD-based chemistry reported here is given in Fig. 1b ...

The most popular of the click reactions, the copper(I)-catalyzed azide ... the starting triflate salt poses minimal risk of toxicity (Nature 2019, DOI: 10.1038/s41586-019-1589-1).

Click chemistry, true to its name ... editorial director at Nature, told STAT. The reaction has especially found use in the polymers and materials chemistry fields. Bertozzi, a chemical ...

Due to the availability of many click reactions with various characteristics, selection of appropriate chemistry for a given application is often not a trivial task. This article gives an overview ...

One of the longstanding challenges in chemical biology has been finding ways to directly observe biological processes at work ...

Chemical biologists quickly realized that click reactions can be a fantastic way to probe living systems like cells because they produce little to no toxic byproducts and can happen quickly.

Tetrazine then participates in a fast click-chemistry reaction with trans-cyclooctene. “It’s a very simple reaction, but of course, we want to do it in a place that’s not simple—inside a ...

Middle molecules with a molecular weight of more than 1,000 are difficult to synthesize due to multiple steps and time-consuming nature ... side reactions and byproducts. By definition, click ...

The molecules snapped together with each other and nothing else, in a reaction that Olof Ramström, a member of the Nobel Committee, described as the "crown-jewel of click reactions." "When this ...

The 2022 Nobel Prize in chemistry was awarded to scientists Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless for their development of click chemistry and bioorthogonal chemistry. These ...