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The very first FDA-approved penis-numbing spray is called Promescent — which just sounds like “prom scent”, but whatever — and it promises to slow things down for that special sexual ...
Numbing creams for waxing do work and can reduce pain during the procedure, though you shouldn't make it a habit of using them too often, especially for smaller things like tweezing.
Of course numbing the pain away doesn’t exactly address the whole process of restructuring your foot in order to jimmy it into a shoe (and then walk on that mess).