Oncolytic virotherapy has been classified as another form of novel immunotherapy 1,2,10, and in addition to herpes virus, vectors such as vaccinia virus have demonstrated promise in this arena.

Ovarian cancer is the second most common gynecological malignancy, afflicting 22 430 women in the United States and 190 000 women worldwide annually. The majority of women present with FIGO ...

The new approach to pancreatic cancer therapy developed by the researchers in the U.K. and China, employs an oncolytic Vaccinia virus that has been modified to improve its safety, ability to ...

The oral presentation entitled “Utilizing Novel Oncolytic Vaccinia Virus for Selective Expression of Immunotherapeutic Proteins in Metastatic Tumors” includes key proof-of-concept data ...

We designed an oncolytic Vaccinia virus that expresses leptin and used it to treat aggressive genetically-induced melanomas. While wild-type oncolytic Vaccinia showed some response, leptin-engineered ...

The Calidi Biotherapeutics SuperNova platform leverages allogeneic stem cells loaded with oncolytic vaccinia virus. Our cell-based platform protects the virus and drives efficacy in three ways, a ...

The researchers first developed a head-and-neck squamous cell carcinoma (HNSCC) cell line that is very sensitive to an oncolytic virus called vaccinia. Tumors injected with the virus regress after ...

The researchers first developed a head-and-neck squamous cell carcinoma (HNSCC) cell line that is very sensitive to an oncolytic virus called vaccinia. Tumors injected with the virus regress after ...

More information: Juan J. Rojas et al, A new MVA ancestor-derived oncolytic vaccinia virus induces immunogenic tumor cell death and robust antitumor immune responses, Molecular Therapy (2024).

Oncolytic virus immunotherapy has been proposed as a step forward for cancer treatment because it can kill cancer cells while activating the immune system. However, its current clinical application is ...

Vaccinia viruses are therapeutic tools with ... For this reason, they are called immune-oncolytic viruses and are the basis of viral immunotherapy. However, these viral strains have reduced ...