This is in striking contrast to the known function of the ornithine cycle, as arginine appears to be the primary source for the excessive ammonia production here. Only in arginine-deficient ...

Ammonia can be produced by the break-down of amino acids, or by the gut bacteria in humans. If the level of ammonia in the blood becomes too high, then it becomes toxic to the brain. The urea ...

Because putrescine’s biochemical precursors, arginine and ornithine, are part of the urea cycle, Ju and colleagues examined how this cycle changed in response to Aβ. In astrocytes exposed to 1 μM ...

and ornithine transcarbamylase (OTC) deficiency and L-arginine is used in case of argininosuccinate synthase deficiency and citrullinemia to catalyze the enzymes in urea cycle and support optimum ...

Urea cycle disorders (UCDs ... The genes tell your child’s body how to break down protein. One UCD, called ornithine transcarbamylase (OTC) deficiency, is what doctors call a sex-linked disorder.

Ornithine transcarbamylase (OTC) deficiency is a urea cycle disorder caused by a genetic mutation in the OTC gene resulting in excess levels of ammonia in the blood. This accumulation can lead to ...

However, this isn't as beneficial as it sounds. The group found that the switching on of the urea cycle causes the production of ornithine, another metabolite that accumulates in the cell and ...

Ornithine is a non-protein-making amino acid and a precursor to two amino acids -- arginine and proline. It has been found to perform several physiological functions, such as reducing fatigue and ...