and the RANK/RANKL/osteoprotegerin (OPG) pathway. Using data pertaining to these three biological pathways as examples, we illustrate possible principles of personalized therapy for osteoporosis.

OPG was identified through a genomics-based ... RANKL inhibition was shown to: increase bone mass and strength in animal models of osteoporosis; reduce tumour-induced osteolysis and tumour burden ...

Osteoporosis, a common bone disease ... Estrogen helps regulate bone metabolism by inhibiting the RANKL/OPG system and lowering levels of pro-inflammatory markers like TNF-α and IL-6.

Follow along on our year-long guide to Osteoporosis, an exploration of the latest recommendations and research on diagnosis, treatment, and management of this bone disease that is the major cause ...

It’s estimated more than 10 million Americans over the age of 50 live with osteoporosis, a bone disease that causes the bones to become weak and brittle. Osteoporosis, in and of itself ...

Although you can’t completely reverse osteoporosis, there are ways to manage it. Some of those methods are things you can do every day through diet and exercise. Your doctor may also recommend ...

Osteoporosis is characterized by an imbalance in bone renewal, where bone loss outpaces bone replacement, leading to weakened, brittle bones. Various factors contribute to osteoporosis, including ...

Osteoporosis — a disease that thins and weakens bones, making them more likely to break — afflicts about 10 million people in the United States age 50 and older, and four times more women than ...

and the RANK/RANKL/osteoprotegerin (OPG) pathway. Using data pertaining to these three biological pathways as examples, we illustrate possible principles of personalized therapy for osteoporosis.