Share on Pinterest Researchers have discovered a p53 gene mutation that prevented pancreatic cancer in mice. Researchers found that mice that possessed a specific mutation in the p53 gene were ...

But when it mutates and becomes defective in cells, the protein can significantly boost a person's ... of the mutant p53 protein are critical for driving cancer growth. Mutations of this protein ...

However, every person who has been exposed to sunlight ... Exposure to sunlight continually created new mutations that outcompeted the p53 mutations. We found the skin looked completely normal ...

The gene p53 has long been a target of intense research in the oncology community because in its unaltered form it suppresses cancer. Mutations in p53 are known to promote the formation of several ...

Detection of p53 mutations was made by single-strand conformation polymorphism (SSCP) analysis of exons 5 to 8 of the gene, and mutations were determined by direct sequencing of exons with abnormal ...

Mutant p53 proteins not only lose ... Li–Fraumeni carriers with codon 248 mutations display earlier tumor onset and higher tumor numbers per person at risk than Li–Fraumeni carriers with ...

Researchers at Baylor College of Medicine have conducted the most comprehensive study of TP53 mutations to better understand the processes leading to the inactivation of this important gene. Their ...

The TP53 gene provides instructions for creating a protein called p53, and the RB1 gene ... for potential inherited genetic mutations that may increase a person’s risk of developing certain ...

We investigated whether mutations in the TP53 gene or the degree of expression of p53 protein in high-grade gliomas is associated with progression-free survival in children with these tumors.

Without action from p53, cancer can easily take hold: in more than half of all human cancers, the gene's function has been lost through random mutations. The scientists virtually modeled and ...

Here, we report on members of families with the Li–Fraumeni syndrome who carry germline mutations in TP53, the gene encoding the tumor-suppressor protein p53. As compared with family members who ...