However, although many cancers express mutant p53 ... therapies not on the basis of mutant versus wild-type p53, but on which mutation is present. These challenging questions will provide exciting ...

highlighting diversity in properties of the different types of p53 mutations, thereby indicating that mutations found in human cancers can behave differently, and thus, need to be carefully ...

After analyzing this large data sample, they have a more thorough understanding of how the TP53 gene mutation impacts cancer. The team found that across all cancer types studied, TP53 mutations ...

In colorectal cancers, β-catenin accumulation ... which displayed both p53 and β-catenin mutations, and SK-Hep1 wild type for both p53 and β-catenin. We also tested whether the increase in ...

They analyzed 617,354 mutations ... carcinomas had mutant p53, like 94.6 percent of ovarian cancers and one of the breast cancer clusters. Although these tumor types might not initially appear ...

Skin cancer is the most common type of human ... Exposure to sunlight continually created new mutations that outcompeted the p53 mutations. We found the skin looked completely normal after we ...

Until now, researchers have assumed that the process is the same with all mutation types. A research ... proliferation (e.g., ...

Mutations to the gene that codes for p53 lead to inactive versions of the ... could lead to a drug that addresses many different cancer types, said the MD Anderson Cancer Center’s Ecaterina ...

The frequency of TP53 mutations varies by tumor type and can be influenced by cell-specific factors and co-mutated oncogenes, which interact with mutant p53 to enhance cancer progression.

After analyzing this large data sample, they have a more thorough understanding of how the TP53 gene mutation impacts cancer. The team found that across all cancer types studied, TP53 mutations were ...