Similar to mice, variation in human SNPs also affected PPAR-gamma binding to DNA regulatory switches, allowing the researchers to "interrogate" these SNPs in powerful large human genetic studies.

PPAR alpha is thought to be one of the main targets of drugs called fibrates, used to lower triglyceride levels. PPAR gamma was the main target of the diabetes drugs Actos, from Takeda, and ...

The drugs in question are from the thiazolidinedione (TZD) class of anti-diabetic therapies, known as PPAR-gamma ligands. They bind to PPAR-gamma, a protein associated with multiple myeloma and ...

Similar to mice, variation in human SNPs also affected PPAR-gamma binding to DNA regulatory switches, allowing the researchers to "interrogate" these SNPs in powerful large human genetic studies.