The team used a careful process of chemical engineering to create their mini prion, before putting it ... that a mutation in the protein changes the structure of the water around it, which in ...

It is the original example of a group of diseases, known as the "transmissible spongiform encephalopathies" (TSE), sometimes known as the "prion" diseases. The diseases include Creutzfeldt Jakob ...

Their pathologic effects are related to their propensity to form insoluble aggregates dominated by β-sheet structures. The mechanisms by which the Aβ peptide forms amyloid deposits remains unknown on ...

This altered water structure influences the protein's ability to adopt its abnormal shape. The study, "Water-directed pinning is key to tau prion formation," is published in the Proceedings of the ...

Limitations of the three putative mechanisms of amyloid fibril assembly for explaining Sup35 prion formation have ... Quaternary structure formation (assembly) and β-sheet formation appear ...

By comparing structures of wild-type and mutant prion proteins, her group highlights structural ... her group compared wild-type and variant enzyme structures in order to understand the molecular and ...

Precisely because the structure and general lessons ... than any other revelation churned out by molecular biologists in recent years. But prions challenge a central tenet of modern biology ...

The Prion Chemical Biology Network invites you to participate in the 1st International Symposium on Prion Chemical Biology and Enabling Technologies – Towards a Cure for Alzheimer's Disease at the ...

Theoretical modelling using molecular dynamics and bioinformatics as tools together with various labelling techniques are being developed in Prof. Chen's group for the prediction of abnormal prion ...