Researchers use peptide arrays to investigate questions about prion recognition, amyloid fibril nucleation and the sequence basis for species barriers. Ever since the 'mad cow' disease epidemic in ...

Limitations of the three putative mechanisms of amyloid fibril assembly for explaining Sup35 prion formation have led to the introduction of a fourth model — nucleated conformational conversion ...

Curcumin has been found to inhibit prion fibril formation and conversion of normal prion protein to its infectious isoform.