Amyloid fibrils are self-associating protein aggregates with a common cross–β-sheet structure 1 ... fibrils formed by the Sup35 prion protein of Saccharomyces cerevisiae are of particular ...

Cryo-EM structure of disease-related prion fibrils provides insights into seeding barriers. Nature Structural & Molecular Biology , 2022; DOI: 10.1038/s41594-022-00833-4 Cite This Page : ...

This altered water structure influences the protein's ability to adopt its abnormal shape. The study, "Water-directed pinning is key to tau prion formation," is published in the Proceedings of the ...