If there is no nucleic acid, how are agent properties specified? Secondly, PrP (sometimes called prion protein) , is associated with the agent somehow - but what does it do? This debate matters ...

What are they? The prion protein (PrP) is a widely expressed, membrane-associated protein transcribed from the PRNP gene, which is highly conserved among mammals. PrPs exist in two forms: a common, ...

These observations suggest that a diagnostic test for prion infections based on CSF or other non-brain tissues or excretia may be possible. Further studies will be required to demonstrate the ...

The most common cause of inherited prion diseases is the E200K mutation of the prion protein (PrP). It is often thought that this mutation causes disease by making PrP more susceptible to ...

In TSEs the normal cellular prion protein (PrP C) is transformed into an infectious disease-associated isoform, PrP Sc — a potential target for immunotherapy. In the March 6 Nature, Anthony R. White ...

They are caused by an abnormal form of a protein called PrP (prion protein). Prions can be transmitted from one person or animal to another through contaminated tissue or body fluids such as blood ...

The development of a sensitive in vitro method to amplify the pathological form of the prion protein might provide a tool for the pre-clinical diagnosis of prion diseases. Currently available ...

Molecular Neurodegeneration. This advanced course covers several of the most important molecules involved in neurodegenerative disease, including Aβ, tau, apoE, TDP-43, α-synuclein, LRRK2, prion ...