Fifty years since its discovery, scientists have finally worked out how a molecular machine found in mitochondria, the ...

The researchers identified the structure of this machine, the mitochondrial pyruvate carrier (MPC), and 50 years since its discovery, have shown how it operates like the lock on a canal to transport ...

After more than five decades of mystery, scientists have finally unveiled the detailed structure and function of a ...

Likewise, there are certain tumour cells that rely on pyruvate metabolism, such as in some types of prostate cancer. These cancers tend to be very ‘hungry’, producing excess pyruvate transport ...

pyruvate carboxylase deficiency; VLCADD, very long chain acyl-CoA dehydrogenase deficiency. Adapted with permission from Ward JC. Inborn errors of metabolism of acute onset in infancy. Pediatr Rev ...