Once activated, Ras can do a variety of things. In this example, it activates an enzymatic cascade of MAP kinases ... activates an enzyme called a kinase. Learn how kinases initiate a signaling ...

The mitogen-activated protein kinase (MAPK) pathway controls the growth and survival of a broad spectrum of human tumours. Activating mutations in RAS and RAF result in activation of the MAPK ...

Erasca, Inc. focuses on developing novel targeted therapies for solid tumors, particularly through the RAS/MAP kinase pathway, with a promising yet early-stage pipeline. The company’s lead ...

We played an important role in revealing the biochemical steps of the RAS-RAF-MAP kinase pathway. We discovered one of the major ways by which RAS oncogenes cause normal cells to become cancerous – ...

Panel A summarizes the conventional model of how oncogenic RAS ... kinase (ERK). AF6 denotes afadin, GAP GTPase-activating protein, GEF guanine exchange factor, MEK mitogen-activated protein ...

"Rasopathies are a group of rare genetic disorders that are caused by mutations in genes that regulate the Ras/mitogen-activated protein kinase (MAPK) signaling pathway." "Given the rarity of this ...