As the PI3K pathway is important for many normal cellular ... are thought to be central to vesicle trafficking and lack a Ras-binding domain. Intriguingly, class III PI3K has been implicated ...
Gupta et al. now use mouse models of Ras-mediated tumorigenesis and validate the importance of the phosphatidylinositol 3-kinase (PI3K) pathway in Ras-induced tumorigenesis. Most of the studies ...
Verastem Oncology (Nasdaq: VSTM), a biopharmaceutical company committed to advancing new medicines for patients with RAS/MAPK ...
The laboratory is studying small molecules that selectively inhibit the components of RAS-RAF-MEK-ERK and PI3K-AKT-mTOR pathways. These compounds are being used as reagents to define the role of these ...
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Exploring the intricate signaling pathways in colorectal cancer: Implications for targeted therapiesThe review explores strategies to overcome this resistance, focusing on targeting downstream molecules within the RAS-RAF-MEK-ERK and PI3K-AKT-mTOR pathways. Furthermore, the study explores the ...
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New insights into therapy resistance in breast cancerA new review was published in Oncotarget, Volume 16, on March 13, 2025, titled "Signaling pathway dysregulation in breast cancer." In this review article, Dinara Ryspayeva and colleagues from Brown ...
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