The Ras/Raf/mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway is often implicated in sensitivity and resistance to leukemia therapy. Dysregulated signaling ...

Figure 1: An overview of the Ras-Raf-MEK-ERK cascade.. The Ras-Raf-MEK-ERK cascade is a complex pathway – not only because it is swamped with acronyms. One term is often used to designate multiple ...

KRAS activates signaling downstream of the RAF, PI3K and RAL pathways, which have been firmly established as direct effectors of oncogenic RAS-mediated cellular transformation (Figure 1).

Panel A summarizes the conventional model of how oncogenic RAS guanosine triphosphatases (i.e., Kirsten rat sarcoma viral oncogene homologue [KRAS], neuroblastoma RAS viral oncogene homologue ...

Corruption of Cellular Growth Signaling. The Ras/Erk pathway is complex, but at its core is a cascade of four proteins – Ras, Raf, Mek, and Erk – that activate one another like a chain of falling ...

In turn, these are capable of phosphorylating Ras-Raf isoforms, changing their behavior towards particular substrates, or enhancing interactions with other signaling factors. 93,94 As previously ...

Please use one of the following formats to cite this article in your essay, paper or report: APA. Tocris Bioscience. (2020, June 18). RAS Oncoprotein Drug Discovery.

The laboratory is studying small molecules that selectively inhibit the components of RAS-RAF-MEK-ERK and PI3K-AKT-mTOR pathways. These compounds are being used as reagents to define the role of these ...

We observed a trend for inactivation of the Ras/Raf/MAK signaling pathway in 12 pts (71%) patients and 2 out of these 12 pts with no evidence of residual DCIS. Interestingly, 5 of these pts had ...

In normal health, Ras signaling is central to the regulation of intracellular signaling networks involved in cell proliferation, growth and survival. Like many cellular signaling pathways, however, ...

Optogenetics Reveals Corruption of Cellular Growth Signaling by Mutations, Drugs. The Ras/Erk pathway is complex, but at its core is a cascade of four proteins -- Ras, Raf, Mek, and Erk -- that ...